Human Donor 3: Patient 355 (59yr old Male, infected with genotype 1a HCV, baseline viral load 467,000 IU/ml) received a prime vaccination of ChAd3-NSmut (2.5x1010 viral particles) and an MVA-NSmut (2x108 plaque forming units) boost vaccination 8 weeks later. Seroconversion after vaccination was confirmed by assaying the neutralizing antibody titers for YF-17D. Human Donor 2: A healthy volunteer was vaccinated with a single dose (0.5 ml containing at least 105 PFU) of 17D live-attenuated yellow fever vaccine strain administered subcutaneously. Mouse LCMV: Female C57BL/6 mice (The Jackson Laboratory), aged 7 weeks, were infected with 2x105 plaque forming units (PFU) LCMV Armstrong intraperitoneally i.p. GEO help: Mouse over screen elements for information.
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